According to what has been said, it is clear that the use of Lcarnitine and its esters, acetyl-L-carnitine and propionyl-L-carnitine, is effective in determining an improvement in sperm parameters and in particular of the total motility and progressive motility, reduces the levels of ROS in seminal fluid, and would be able to improve the quality of the semen, also in case of cryopreservation. The administration of these molecules in the treatment of male infertility (alone or in combination) is, therefore, a rational and effective therapeutic strategy. However, clinical benefits should not be achieved at high dose, since the evidence of calcium chelator activity of L-carnitine that may determine cell damage and decrease in serum calcium.
